Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arf6tm1Yaka
Name:	ADP-ribosylation factor 6; targeted mutation 1, Yasunori Kanaho
MGI ID:	MGI:3662650
Synonyms:	Arf6-
Gene:	Arf6  Location: Chr12:69418924-69420557 bp, + strand  Genetic Position: Chr12, 28.81 cM
Alliance:	Arf6tm1Yaka page

Germline Transmission:	Earliest citation of germline transmission: J:111404
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A vector was designed to replace a fragment encompassing the ATG with a neomycin resistance cassette. Western blot failed to detect protein in mutant MEFs. (J:111404)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arf6 Mutation:	10 strains or lines available

Original:	J:111404 Suzuki T, et al., Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol. 2006 Aug;26(16):6149-56
All:	4 reference(s)