Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mavstm1Zjc
Name:	mitochondrial antiviral signaling protein; targeted mutation 1, Zhijian J Chen
MGI ID:	MGI:3654145
Synonyms:	Mavs-
Gene:	Mavs  Location: Chr2:131075983-131089945 bp, + strand  Genetic Position: Chr2, 63.3 cM
Alliance:	Mavstm1Zjc page

Germline Transmission:	Earliest citation of germline transmission: J:110905
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence beginning at the ATG in exon 2 and extending through exon 3 was replaced with a floxed neomycin resistance gene. Immunoblot failed to detect protein in mutants. (J:110905)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

16 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mavs Mutation:	36 strains or lines available

Original:	J:110905 Sun Q, et al., The specific and essential role of MAVS in antiviral innate immune responses. Immunity. 2006 May;24(5):633-42
All:	98 reference(s)