Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd8b1tm1Litt
Name:	CD8 subunit beta 1; targeted mutation 1, Dan R Littman
MGI ID:	MGI:3654103
Synonyms:	CD8beta0, CD8betanull
Gene:	Cd8b1  Location: Chr6:71299772-71314476 bp, + strand  Genetic Position: Chr6, 32.14 cM
Alliance:	Cd8b1tm1Litt page

Germline Transmission:	Earliest citation of germline transmission: J:112551
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exon 2 and part of intron 3 with a neomycin resistance gene. The result was a loss of 37% of the coding sequence, including most of the immunoglobulin-like domain and the entire J-like region. (J:112551)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd8b1 Mutation:	20 strains or lines available

Original:	J:112551 Crooks ME, et al., Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain. Immunity. 1994 Jul;1(4):277-85
All:	9 reference(s)