Map2tm1Zhku
Targeted Allele Detail
|
|
| Symbol: |
Map2tm1Zhku |
| Name: |
microtubule-associated protein 2; targeted mutation 2, Z Khuchua |
| MGI ID: |
MGI:3653757 |
| Synonyms: |
delta1-158 |
| Gene: |
Map2 Location: Chr1:66214432-66481742 bp, + strand Genetic Position: Chr1, 33.49 cM
|
| Alliance: |
Map2tm1Zhku page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:110727
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
129X1/SvJ
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: A targeting vector was designed to replace exon 2 with a neomycin resistance gene. This exon was 285-bp long and contained the translation start site and the RII bonding site. Mutants would putatively generate a truncated protein, translated from the next in-frame ATG site in exon 3. Western blot demonstrated that mutants expressed more Mtap2 antigen than wild-type animals. Transcript levels were also increased, suggesting that some modulating regulatory elements are present within the targeted sequence deleted from the locus.
(J:110727)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Map2 Mutation: |
108 strains or lines available
|
|
| Original: |
J:110727 Khuchua Z, et al., Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory. Neuroscience. 2003;119(1):101-11 |
| All: |
1 reference(s) |
|
Analysis Tools
