Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nup98tm1Bmaf
Name:	nucleoporin 98; targeted mutation 1, Beatriz M A Fontoura
MGI ID:	MGI:3653729
Synonyms:	Nup96-
Gene:	Nup98  Location: Chr7:101768607-101859359 bp, - strand  Genetic Position: Chr7, 54.71 cM
Alliance:	Nup98tm1Bmaf page

Germline Transmission:	Earliest citation of germline transmission: J:110907
Parent Cell Line:	iTL1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: A targeting vector was designed to incorporate a 3-way stop codon at the 5' end of exon 21 and a neo cassette upstream of exon 21 that was subsequently removed via cre mediated recombination. Mutants demonstrated that the unique sequence of Nup96 was abolished and exon 20, which encodes the 6 kDa polypeptide shared by Nup98 and Nup96, was maintained so that expression of Nup98 remained uninterrupted. (J:110907)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nup98 Mutation:	146 strains or lines available

Original:	J:110907 Faria AM, et al., The nucleoporin Nup96 is required for proper expression of interferon-regulated proteins and functions. Immunity. 2006 Mar;24(3):295-304
All:	1 reference(s)