Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chgatm1Gnh
Name:	chromogranin A; targeted mutation 1, Geoffrey N Hendy
MGI ID:	MGI:3653689
Synonyms:	Chga-
Gene:	Chga  Location: Chr12:102521228-102531287 bp, + strand  Genetic Position: Chr12, 51.66 cM
Alliance:	Chgatm1Gnh page

Germline Transmission:	Earliest citation of germline transmission: J:111025
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting construct was designed to replace exons 1-4 with a neomycin resistance gene. Adrenal expression of the protein was undetectable in mutants. There was no evidene of a read through transcript derived from the remaining exons. (J:111025)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Chga Mutation:	33 strains or lines available

Original:	J:111025 Hendy GN, et al., Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Mol Endocrinol. 2006 Aug;20(8):1935-47
All:	2 reference(s)