Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptentm1.1Hwu
Name:	phosphatase and tensin homolog; targeted mutation 1.1, Hong Wu
MGI ID:	MGI:3653378
Synonyms:	Pten-, Ptendelta5
Gene:	Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance:	Ptentm1.1Hwu page

Germline Transmission:	Earliest citation of germline transmission: J:110567
Parent Cell Line:	LW1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: ES cells were transiently transfected with cre recombinase for removal of floxed exon 5 from the locus. (J:110567)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptentm1.1Hwu

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:	81 strains or lines available

Original:	J:110567 Freeman D, et al., Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006 Jul 1;66(13):6492-6
All:	13 reference(s)