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Pigatm2Tak
Targeted Allele Detail
Summary
Symbol: Pigatm2Tak
Name: phosphatidylinositol glycan anchor biosynthesis, class A; targeted mutation 2, Junji Takeda
MGI ID: MGI:3652879
Gene: Piga  Location: ChrX:163202814-163216912 bp, + strand  Genetic Position: ChrX, 76.49 cM, cytoband F3-F4
Alliance: Pigatm2Tak page
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:32798
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A targeting vector was used to replace exon 2 with a PGK-neo. (J:32798)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Piga Mutation:  3 strains or lines available
Notes
Mice are only studied as chimeras since the targeted mutation of this X-linked marker was accomplished in male ES cells and no viable mouse line can be established.
References
Original:  J:32798 Kawagoe K, et al., Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria. Blood. 1996 May 1;87(9):3600-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory