Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppp1r15atm1Kii
Name:	protein phosphatase 1, regulatory subunit 15A; targeted mutation 1, Ken-ichi Isobe
MGI ID:	MGI:3641226
Synonyms:	Gadd34-
Gene:	Ppp1r15a  Location: Chr7:45172341-45175692 bp, - strand  Genetic Position: Chr7, 29.34 cM, cytoband B2
Alliance:	Ppp1r15atm1Kii page

Germline Transmission:	Earliest citation of germline transmission: J:110590
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace the 0.2 kb genomic fragment containing part of the second exon with a neo cassette. Western blot confirmed absence of protein in mutant MEFs. (J:110590)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp1r15a Mutation:	22 strains or lines available

Original:	J:110590 Kojima E, et al., The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB J. 2003 Aug;17(11):1573-5
All:	10 reference(s)