Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncoa1tm1Jkr
Name:	nuclear receptor coactivator 1; targeted mutation 1, Janardan K Reddy
MGI ID:	MGI:3641219
Synonyms:	SRC-1-
Gene:	Ncoa1  Location: Chr12:4297362-4527182 bp, - strand  Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
Alliance:	Ncoa1tm1Jkr page

Germline Transmission:	Earliest citation of germline transmission: J:53063
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace most of exon B with a neomycin resistance cassette. RT-PCR confirmed absence of transcript in mutant kidney, liver and colon samples. Northern and Western blot analyses confirmed ablation of the locus. (J:53063)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa1 Mutation:	169 strains or lines available

Original:	J:53063 Qi C, et al., Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1585-90
All:	7 reference(s)