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Ms4a1tm1Msn
Targeted Allele Detail
Summary
Symbol: Ms4a1tm1Msn
Name: membrane-spanning 4-domains, subfamily A, member 1; targeted mutation 1, Michael S Neuberger
MGI ID: MGI:3640301
Synonyms: CD20-
Gene: Ms4a1  Location: Chr19:11227043-11243513 bp, - strand  Genetic Position: Chr19, 8.19 cM, cytoband B
Alliance: Ms4a1tm1Msn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48688
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encoding transmembranes 3 and 4 was replaced with a neomycin resistance cassette. Absence of transcript was confirmed by Northern blot analysis. (J:48688)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ms4a1 Mutation:  23 strains or lines available
Notes
These mice have a decrease in the IgMhi 6B2- sub-population of peritoneal IgM+ cells but this is the result of a strain background effect and is also seen in mice of the 129/SvEv-Gpilc strain (strain of origin for the CCB ES cell line).
References
Original:  J:48688 O'Keefe TL, et al., Mice carrying a CD20 gene disruption. Immunogenetics. 1998 Jul;48(2):125-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory