Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncstntm1Rroz
Name:	nicastrin; targeted mutation 1, Richard Rozmahel
MGI ID:	MGI:3629090
Synonyms:	Ncstntm1Ut
Gene:	Ncstn  Location: Chr1:171893580-171910356 bp, - strand  Genetic Position: Chr1, 79.54 cM
Alliance:	Ncstntm1Rroz page

Germline Transmission:	Earliest citation of germline transmission: J:108976
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced exon 3. RT-PCR demonstrated absence of wild-type protein in mutants. (J:108976)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncstn Mutation:	33 strains or lines available

Original:	J:108976 Nguyen V, et al., Loss of nicastrin elicits an apoptotic phenotype in mouse embryos. Brain Res. 2006 May 1;1086(1):76-84
All:	2 reference(s)