Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ddotm1Rdl
Name:	D-aspartate oxidase; targeted mutation 1, Roberto Di Lauro
MGI ID:	MGI:3628810
Synonyms:	Ddo-
Gene:	Ddo  Location: Chr10:40506007-40557843 bp, + strand  Genetic Position: Chr10, 22.0 cM, cytoband B1
Alliance:	Ddotm1Rdl page

Germline Transmission:	Earliest citation of germline transmission: J:109184
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A pgk-neo cassette replaced exons 0-2. Western blot analysis of kidney, brain and spleen confirmed that protein was absent in mutants. (J:109184)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

27 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddo Mutation:	14 strains or lines available

Original:	J:109184 Errico F, et al., A physiological mechanism to regulate d-aspartic acid and NMDA levels in mammals revealed by d-aspartate oxidase deficient mice. Gene. 2006 Jun 7;374:50-7
All:	8 reference(s)