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Terttm1Rdp
Targeted Allele Detail
Summary
Symbol: Terttm1Rdp
Name: telomerase reverse transcriptase; targeted mutation 1, Ronald DePinho
MGI ID: MGI:3628579
Synonyms: mTert1-
Gene: Tert  Location: Chr13:73775030-73797962 bp, + strand  Genetic Position: Chr13, 40.12 cM
Alliance: Terttm1Rdp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108914
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1, containing the ATG and encoding the RNA/DNA binding domain, was deleted. Activity of the mutant protein was not detected in the TRAP assay. (J:108914)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tert Mutation:  52 strains or lines available
References
Original:  J:108914 Farazi PA, et al., Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res. 2006 May 1;66(9):4766-73
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory