Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Rasgrp3tm1Jstn
Name:	RAS, guanyl releasing protein 3; targeted mutation 1, James C Stone
MGI ID:	MGI:3625862
Synonyms:	Rasgrp3-
Gene:	Rasgrp3  Location: Chr17:75742891-75836049 bp, + strand  Genetic Position: Chr17, 46.55 cM
Alliance:	Rasgrp3tm1Jstn page

Germline Transmission:	Earliest citation of germline transmission: J:108677
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P3/J

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 2, interrupting the coding sequence downstream of codon 40 in the Ras exchange motif of the catalytic region. (J:108677)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rasgrp3 Mutation:	42 strains or lines available

Original:	J:108677 Coughlin JJ, et al., RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol. 2005 Dec 1;175(11):7179-84
All:	5 reference(s)