Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Xrcc6tm1Gcl
Name:	X-ray repair complementing defective repair in Chinese hamster cells 6; targeted mutation 1, Gloria C Li
MGI ID:	MGI:3625858
Synonyms:	Ku70-
Gene:	Xrcc6  Location: Chr15:81872036-81924286 bp, + strand  Genetic Position: Chr15, 38.33 cM, cytoband E-F
Alliance:	Xrcc6tm1Gcl page

Germline Transmission:	Earliest citation of germline transmission: J:108657
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 336 bp in exon 2, including the ATG, by homologous recombination. Western blot confirmed absence of protein in mutant ear fibroblasts and embryo fibroblasts. (J:108657)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xrcc6 Mutation:	61 strains or lines available

Original:	J:108657 Ouyang H, et al., Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. J Exp Med. 1997 Sep 15;186(6):921-9
All:	7 reference(s)