Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	H6pdtm1Pmst
Name:	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase); targeted mutation 1, Paul M Stewart
MGI ID:	MGI:3624665
Gene:	H6pd  Location: Chr4:150063932-150093480 bp, - strand  Genetic Position: Chr4, 80.65 cM
Alliance:	H6pdtm1Pmst page

Germline Transmission:	Earliest citation of germline transmission: J:108281
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3 were replaced by a neomycin resistance gene. Absence of protein was confirmed by immunoblot of mutant liver microsomes. (J:108281)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any H6pd Mutation:	60 strains or lines available

Original:	J:108281 Lavery GG, et al., Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation. J Biol Chem. 2006 Mar 10;281(10):6546-51
All:	9 reference(s)