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Trp53tm3Wahl
Targeted Allele Detail
Summary
Symbol: Trp53tm3Wahl
Name: transformation related protein 53; targeted mutation 3, Geoffrey M Wahl
MGI ID: MGI:3624429
Synonyms: p53deltaP
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm3Wahl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:108183
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting construct was used to remove sequence coding for six prolines and both PXXP motifs (p.E75_S91del). Quantification of mRNAs from mutant and wild-type demonstrated identical transcription from both alleles. (J:108183)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Trp53tm3Wahl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  232 strains or lines available
References
Original:  J:108183 Toledo F, et al., A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell. 2006 Apr;9(4):273-85
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory