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Rtn4tm1Schw
Targeted Allele Detail
Summary
Symbol: Rtn4tm1Schw
Name: reticulon 4; targeted mutation 1, Martin E Schwab
MGI ID: MGI:3623522
Synonyms: Nogo-, Nogo-A-, nogo-aEIII, NogoA KO
Gene: Rtn4  Location: Chr11:29642947-29694331 bp, + strand  Genetic Position: Chr11, 16.79 cM
Alliance: Rtn4tm1Schw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107700
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced parts of exons 2 and 3. Isoform A was not detectable in tissues of mutants. Protein from isoform A was not detected by immunoblot analysis. (J:107700)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 29 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rtn4 Mutation:  130 strains or lines available
References
Original:  J:107700 Simonen M, et al., Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron. 2003 Apr 24;38(2):201-11
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory