Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hcls1tm2Wtn
Name:	hematopoietic cell specific Lyn substrate 1; targeted mutation 2, Takeshi Watanabe
MGI ID:	MGI:3623118
Synonyms:	HS13'ko
Gene:	Hcls1  Location: Chr16:36755345-36783574 bp, + strand  Genetic Position: Chr16, 26.3 cM, cytoband B
Alliance:	Hcls1tm2Wtn page

Germline Transmission:	Earliest citation of germline transmission: J:28146
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Disruption caused by insertion of vector   Mutation details: Exon 10 was disrupted by the insertion of a lacZ-neo cassette. A truncated protein comprised of residues 1-237 could potentially be produced, but would lack the acidic and amphipathic alpha-helix structure and the SH3 region. Protein was not detected in mutants. (J:28146)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcls1 Mutation:	26 strains or lines available

Original:	J:28146 Taniuchi I, et al., Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases. EMBO J. 1995 Aug 1;14(15):3664-78
All:	2 reference(s)