Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nos1tm2Plh
Name:	nitric oxide synthase 1, neuronal; targeted mutation 2, Paul L Huang
MGI ID:	MGI:3621899
Gene:	Nos1  Location: Chr5:118004904-118096905 bp, + strand  Genetic Position: Chr5, 57.29 cM, cytoband F
Alliance:	Nos1tm2Plh page

Germline Transmission:	Earliest citation of germline transmission: J:106816
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 6 was removed via cre-mediated recombination. This exon encodes the heme-binding domain. RT-PCR confirmed the loss of exon 6 in mutants, demonstrating presence of some mRNA containing exon 2, but none containing exon 6. Immunohistochemistry failed to detect any staining in the cytoplasm, neurites, varicosities, cortex or striatum of mutants. (J:106816)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nos1 Mutation:	82 strains or lines available

Original:	J:106816 Gyurko R, et al., Deletion of exon 6 of the neuronal nitric oxide synthase gene in mice results in hypogonadism and infertility. Endocrinology. 2002 Jul;143(7):2767-74
All:	8 reference(s)