Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnks2tm1Susm
Name:	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; targeted mutation 1, Susan Smith
MGI ID:	MGI:3621819
Synonyms:	TnksPDdelta
Gene:	Tnks2  Location: Chr19:36811632-36870877 bp, + strand  Genetic Position: Chr19, 31.96 cM
Alliance:	Tnks2tm1Susm page

Germline Transmission:	Earliest citation of germline transmission: J:106917
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exons 25-27, encoding the PARP domain, with a neomycin resistance cassette. The vector was designed using the exon nomenclature in J:71663. This allele was expected to produce a null, however, truncated proteins were expressed from the locus that lacked the catalyitic PARP domain. Smaller proteins putatively contain the ANK and SAM domains and larger proteins are probably variants splicing the truncated protein to the downstream neo. (J:106917)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnks2 Mutation:	48 strains or lines available

Original:	J:106917 Hsiao SJ, et al., Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Mol Cell Biol. 2006 Mar;26(6):2044-54
All:	1 reference(s)