About   Help   FAQ
Mapk14tm1Gab
Targeted Allele Detail
Summary
Symbol: Mapk14tm1Gab
Name: mitogen-activated protein kinase 14; targeted mutation 1, Christopher A Gabel
MGI ID: MGI:3620096
Synonyms: p38alpha-
Gene: Mapk14  Location: Chr17:28910303-28967380 bp, + strand  Genetic Position: Chr17, 14.85 cM
Alliance: Mapk14tm1Gab page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60918
Parent Cell Line:  DBA-252 (ES Cell)
Strain of Origin:  DBA/1LacJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct was designed to replace ~8-10 kb of sequence from phenylalanine 129 to aspartic acid 283, including the TGY dual phosphorylation site, with a neomycin resistance cassette. (J:60918)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  41 strains or lines available
References
Original:  J:60918 Allen M, et al., Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000 Mar 6;191(5):859-70
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory