Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ing1tm1Avg
Name:	inhibitor of growth family, member 1; targeted mutation 1, A V Gudkov
MGI ID:	MGI:3619526
Synonyms:	ing1-
Gene:	Ing1  Location: Chr8:11605762-11613251 bp, + strand  Genetic Position: Chr8, 5.73 cM
Alliance:	Ing1tm1Avg page

Germline Transmission:	Earliest citation of germline transmission: J:105658
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exon 4, common to all transcripts and containing most of the protein coding sequences including the conserved PHD finger domain, with a neomycin resistance gene. Transcript was not detected in mutant MEFS in Northern blot analysis. Western blot failed to detect protein in mutants as well. (J:105658)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ing1 Mutation:	25 strains or lines available

Original:	J:105658 Kichina JV, et al., Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas. Oncogene. 2006 Feb 9;25(6):857-66
All:	2 reference(s)