Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Sufutm1Rto
Name:	SUFU negative regulator of hedgehog signaling; targeted mutation 1, Rune Toftgard
MGI ID:	MGI:3619046
Synonyms:	Sufu-
Gene:	Sufu  Location: Chr19:46385335-46477243 bp, + strand  Genetic Position: Chr19, 38.85 cM
Alliance:	Sufutm1Rto page

Germline Transmission:	Earliest citation of germline transmission: J:105832
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A vector was designed to replace part of the promoter, 5' UTR and first exon, including both transcription and translation start sites, with a neomycin resistance cassette. Northern blot did not detect transcript in mutants and Western blot analysis failed to detect protein. (J:105832)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sufu Mutation:	59 strains or lines available

Original:	J:105832 Svard J, et al., Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell. 2006 Feb;10(2):187-97
All:	9 reference(s)