Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apbb1tm1Her
Name:	amyloid beta precursor protein binding family B member 1; targeted mutation 1, Joachim Herz
MGI ID:	MGI:3615373
Synonyms:	Apbb1tm1Sgnt, Fe65-, p97/60FE65-
Gene:	Apbb1  Location: Chr7:105207690-105230860 bp, - strand  Genetic Position: Chr7, 55.9 cM
Alliance:	Apbb1tm1Her page

Germline Transmission:	Earliest citation of germline transmission: J:105160
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace 6.5 kb of sequence with a pol2neo cassette and a lacZ into exon 2. Deleted sequence contained the C-terminal 77 nucleotides of exon 2, intron 2 and the N-terminal 158 nucleotides of exon 3. Protein was not detected by Western blot analysis. (J:105160)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apbb1 Mutation:	51 strains or lines available

Original:	J:105160 Guenette S, et al., Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J. 2006 Jan 25;25(2):420-31
All:	5 reference(s)