Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Dio1tm1Vag
Name:	deiodinase, iodothyronine, type I; targeted mutation 1, Valerie Anne Galton
MGI ID:	MGI:3613031
Synonyms:	D1KO
Gene:	Dio1  Location: Chr4:107148662-107164365 bp, - strand  Genetic Position: Chr4, 50.18 cM
Alliance:	Dio1tm1Vag page

Germline Transmission:	Earliest citation of germline transmission: J:104508
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon two, containing the TGA selenocysteine codon, was replaced with the neo cassette. Protein activity was not detected in mutant liver, kidney, thyroid or pituitary tissues. (J:104508)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dio1 Mutation:	16 strains or lines available

Original:	J:104508 Schneider MJ, et al., Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology. 2006 Jan;147(1):580-9
All:	13 reference(s)