Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lrattm1Log
Name:	lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1, Lorraine J Gudas
MGI ID:	MGI:3612421
Synonyms:	Lrat-
Gene:	Lrat  Location: Chr3:82799889-82811281 bp, - strand  Genetic Position: Chr3, 36.81 cM
Alliance:	Lrattm1Log page

Germline Transmission:	Earliest citation of germline transmission: J:104101
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was designed to replace exon 1, containing the ATG start codon, with a neomycin resistance gene flanked by loxP sites. Transcript was not detected in mutant kidney, intestine, brain, lung or liver samples by RT-PCR. (J:104101)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrat Mutation:	26 strains or lines available

Original:	J:104101 Liu L, et al., Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency. J Biol Chem. 2005 Dec 2;280(48):40226-34
All:	4 reference(s)