Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3c2btm1.1Pkha
Name:	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; targeted mutation 1.1, Paul A Khavari
MGI ID:	MGI:3611683
Synonyms:	C2beta-
Gene:	Pik3c2b  Location: Chr1:132973410-133036429 bp, + strand  Genetic Position: Chr1, 57.75 cM
Alliance:	Pik3c2btm1.1Pkha page

Germline Transmission:	Earliest citation of germline transmission: J:103754
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cre mediated recombination resulted in the deletion of exons 3-5. Loss of this sequence produced a truncated, nonfunctional protein lacking the PIK, catalytic, and C2 domains that are required for induction of keratinocyte differentiation in vitro. Transcript was not detected in keratinocytes from mutants. Western blot failed to detect protein in mutant epidermis as well as brain and testis. (J:103754)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3c2b Mutation:	81 strains or lines available

Original:	J:103754 Harada K, et al., The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation. Mol Cell Biol. 2005 Dec;25(24):11122-30
All:	4 reference(s)