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Mettl21c Gene Detail
Summary
  • Symbol
    Mettl21c
  • Name
    methyltransferase 21C, AARS1 lysine
  • Synonyms
    A530098C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3611450
    NCBI Gene: 433294
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:44048568-44059194 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 23.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3611450
 protein coding gene Chr1:44048559-44081745 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015984
 protein coding gene Chr1:43047064-43057667 (-)
A/J MGP_AJ_G0015968
 protein coding gene Chr1:41710981-41721607 (-)
AKR/J MGP_AKRJ_G0015923
 protein coding gene Chr1:42287867-42298493 (-)
BALB/cJ MGP_BALBcJ_G0015922
 protein coding gene Chr1:41394555-41405218 (-)
C3H/HeJ MGP_C3HHeJ_G0015755
 protein coding gene Chr1:42665275-42675901 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016375
 protein coding gene Chr1:44780299-44794978 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014097
 protein coding gene Chr1:38552016-38562110 (-)
CAST/EiJ MGP_CASTEiJ_G0015336
 protein coding gene Chr1:42687672-42697820 (-)
CBA/J MGP_CBAJ_G0015727
 protein coding gene Chr1:46078439-46089065 (-)
DBA/2J MGP_DBA2J_G0015828
 protein coding gene Chr1:41015812-41026464 (-)
FVB/NJ MGP_FVBNJ_G0015830
 protein coding gene Chr1:40516537-40527147 (-)
LP/J MGP_LPJ_G0015898
 protein coding gene Chr1:43364354-43374980 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015850
 protein coding gene Chr1:48059332-48069958 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016422
 protein coding gene Chr1:42507422-42518048 (-)
PWK/PhJ MGP_PWKPhJ_G0015119
 protein coding gene Chr1:40890672-40900879 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014901
 protein coding gene Chr1:42532586-42543220 (-)
WSB/EiJ MGP_WSBEiJ_G0015398
 protein coding gene Chr1:42553922-42565271 (-)



Homology
more
  • Human Ortholog
    METTL21C, methyltransferase 21C, AARS1 lysine
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL21C, methyltransferase 21C, AARS1 lysine
  • Synonyms
    C13orf39
  • Links
    NCBI Gene ID: 196541
    neXtProt AC: NX_Q5VZV1
    UniProt: Q5VZV1

  • Chr Location
    13q33.1; chr13:102685747-102704300 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit muscle weakness, impaired exercise endurance, dysregulated autophagy during denervation-induced muscle atrophy, and reduced ATPase activity in skeletal muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    24
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047343 Ensembl Gene Model | MGI Sequence Detail 10627 C57BL/6J ±  kb
    transcript ENSMUST00000061421 Ensembl | MGI Sequence Detail 1086 Not Applicable  
    polypeptide ENSMUSP00000061229 Ensembl | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    • Latest
      J:299134 Zoabi M, et al., Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue. J Biol Chem. 2020 Aug 14;295(33):11822-11832
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory