Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sorbs3tm1Kmor
Name:	sorbin and SH3 domain containing 3; targeted mutation 1, Ken-ichirou Morohashi
MGI ID:	MGI:3611214
Synonyms:	Vinexin gamma-
Gene:	Sorbs3  Location: Chr14:70417917-70449438 bp, - strand  Genetic Position: Chr14, 36.27 cM
Alliance:	Sorbs3tm1Kmor page

Germline Transmission:	Earliest citation of germline transmission: J:102860
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: The gamma-form specific first exon was deleted along with the upstream region upon the insertion of a PGK-neo-pA cassette. Fetal gonads were analyzed by western blot to confirm absence of the gamma and alpha isoforms. The beta isoform is still expressed. (J:102860)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sorbs3 Mutation:	33 strains or lines available

Original:	J:102860 Matsuyama M, et al., A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005 May;10(5):421-34
All:	1 reference(s)