Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adamts1tm1Mlia
Name:	ADAM metallopeptidase with thrombospondin type 1 motif 1; targeted mutation 1, M Luisa Iruela-Arispe
MGI ID:	MGI:3609982
Gene:	Adamts1  Location: Chr16:85590715-85600001 bp, - strand  Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
Alliance:	Adamts1tm1Mlia page

Germline Transmission:	Earliest citation of germline transmission: J:102464
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A targeting vector was used to replace exons 2-8 with a loxP flanked neomycin resistance cassette. Fluorescence immunohistochemical analysis failed to detect protein in mutant. (J:102464)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts1 Mutation:	64 strains or lines available

Original:	J:102464 Lee NV, et al., Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem. 2005 Oct 14;280(41):34796-804
All:	7 reference(s)