Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fancatm1Zqw
Name:	Fanconi anemia, complementation group A; targeted mutation 1, Zhao-Qi Wang
MGI ID:	MGI:3609190
Synonyms:	Fancadelta
Gene:	Fanca  Location: Chr8:123995039-124045315 bp, - strand  Genetic Position: Chr8, 72.1 cM
Alliance:	Fancatm1Zqw page

Germline Transmission:	Earliest citation of germline transmission: J:102526
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A neomycin resistance gene flanked by loxP sites was inserted into intron 36 and a third loxP site was inserted into intron 39. Transient transfection with cre recombinase resulted in the loss of exons 37-39. Western blot failed to detect protein in ES cells and fibroblasts. (J:102526)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fanca Mutation:	81 strains or lines available

Original:	J:102526 Yang YG, et al., The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis. 2005 Oct;26(10):1731-40
All:	1 reference(s)