Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Snapintm1Zhs
Name:	SNAP-associated protein; targeted mutation 1, Zu-Hang Sheng
MGI ID:	MGI:3608768
Synonyms:	snapin KO
Gene:	Snapin  Location: Chr3:90395333-90398320 bp, - strand  Genetic Position: Chr3, 39.24 cM
Alliance:	Snapintm1Zhs page

Germline Transmission:	Earliest citation of germline transmission: J:102725
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: All four coding exons were replaced by a PGKneo cassette via homologous recombination. Southern blot analysis revealed a novel 5.9 kb DNA fragment corresponding to the interrupted gene, however Western blot analysis confirmed absence of protein expression. (J:102725)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snapin Mutation:	11 strains or lines available

Original:	J:102725 Tian JH, et al., The role of Snapin in neurosecretion: snapin knock-out mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. J Neurosci. 2005 Nov 9;25(45):10546-55
All:	7 reference(s)