Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc7a11tm1Hsat
Name:	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; targeted mutation 1, Hideyo Sato
MGI ID:	MGI:3608695
Synonyms:	xCT-
Gene:	Slc7a11  Location: Chr3:50319385-50403947 bp, - strand  Genetic Position: Chr3, 21.72 cM, cytoband D
Alliance:	Slc7a11tm1Hsat page

Germline Transmission:	Earliest citation of germline transmission: J:102902
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: GFP and a Neo cassette were introduced into exon 1 via homologous recombination. Crossing with Cre-recombinase-expressing mice removed the neo cassette. Northern blot analysis confirmed absence of mRNA in brain and thymus and peritoneal macrophages. (J:102902)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc7a11 Mutation:	49 strains or lines available

Original:	J:102902 Sato H, et al., Redox imbalance in cystine/glutamate transporter-deficient mice. J Biol Chem. 2005 Nov 11;280(45):37423-9
All:	25 reference(s)