Cbfa2t2tm1Swh
Targeted Allele Detail
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| Symbol: |
Cbfa2t2tm1Swh |
| Name: |
CBFA2/RUNX1 translocation partner 2; targeted mutation 1, Scott W Hiebert |
| MGI ID: |
MGI:3607923 |
| Synonyms: |
Mtgr1- |
| Gene: |
Cbfa2t2 Location: Chr2:154278401-154381276 bp, + strand Genetic Position: Chr2, 76.62 cM, cytoband C3.2
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| Alliance: |
Cbfa2t2tm1Swh page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:102172
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| Parent Cell Line: |
TL1/TL-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A neomycin resistance gene was inserted into exon 7,
which is within the first conserved domain that is found in all
family members.
RT-PCR analysis confirmed that a transcript lacking exon 7 was expressed from this allele, but both immunoblot analysis, and immunoprecipitation, followed by immunoblot analysis with purified antibodies directed to the
N terminus of indicated that neither a
full-length nor a truncated Mtgr1 protein was produced at
detectable levels.
(J:102172)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cbfa2t2 Mutation: |
211 strains or lines available
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| Original: |
J:102172 Amann JM, et al., Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol. 2005 Nov;25(21):9576-85 |
| All: |
4 reference(s) |
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Analysis Tools
