Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Insig1tm1.1Mbjg
Name:	insulin induced gene 1; targeted mutation 1.1, Joseph L Goldstein
MGI ID:	MGI:3607577
Synonyms:	Insig1-
Gene:	Insig1  Location: Chr5:28276410-28283660 bp, + strand  Genetic Position: Chr5, 13.94 cM
Alliance:	Insig1tm1.1Mbjg page

Germline Transmission:	Earliest citation of germline transmission: J:101203
Parent Cell Line:	SM1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Crossing Insig1tm1Mbjg with mice expressing cre in the germline created this allele in which exon 1 was deleted via cre-mediated recombination. (J:101203)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Insig1 Mutation:	15 strains or lines available

Original:	J:101203 Engelking LJ, et al., Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest. 2005 Sep;115(9):2489-98
All:	2 reference(s)