Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Eif4ebp2tm1Klan
Name:	eukaryotic translation initiation factor 4E binding protein 2; targeted mutation 1, Eric Klann
MGI ID:	MGI:3607258
Synonyms:	4E-BP2 KO
Gene:	Eif4ebp2  Location: Chr10:61268276-61288448 bp, - strand  Genetic Position: Chr10, 32.21 cM, cytoband B4-B5
Alliance:	Eif4ebp2tm1Klan page

Germline Transmission:	Earliest citation of germline transmission: J:102163
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exon 2, disrupting amino acids 49-110. Western blot of hippocampal, cortical and cerebellar extracts confirmed the absence of protein in mutants. (J:102163)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Eif4ebp2tm1Klan

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Eif4ebp2 Mutation:	23 strains or lines available

Original:	J:102163 Banko JL, et al., The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci. 2005 Oct 19;25(42):9581-90
All:	41 reference(s)