Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nr0b2tm1Rus
Name:	nuclear receptor subfamily 0, group B, member 2; targeted mutation 1, David W Russell
MGI ID:	MGI:3607116
Synonyms:	Shp-
Gene:	Nr0b2  Location: Chr4:133280687-133283847 bp, + strand  Genetic Position: Chr4, 66.25 cM
Alliance:	Nr0b2tm1Rus page

Germline Transmission:	Earliest citation of germline transmission: J:102129
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance gene was inserted into exon 1 to disrupt the locus, eliminating the required portions of the ligand binding and dimerization domains. Northern blot analysis of mutant liver failed to detect protein. (J:102129)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr0b2 Mutation:	15 strains or lines available

Original:	J:102129 Kerr TA, et al., Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell. 2002 Jun;2(6):713-20
All:	3 reference(s)