P2rx7tm1Ipch
Targeted Allele Detail
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| Symbol: |
P2rx7tm1Ipch |
| Name: |
purinergic receptor P2X, ligand-gated ion channel, 7; targeted mutation 1, Iain P Chessell |
| MGI ID: |
MGI:3606250 |
| Synonyms: |
Glaxo P2X7R-, P2rx7tm1Blo, P2X7-, P2X7R- |
| Gene: |
P2rx7 Location: Chr5:122781974-122829495 bp, + strand Genetic Position: Chr5, 62.5 cM, cytoband F
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| Alliance: |
P2rx7tm1Ipch page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:101945
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: The targeting event results in the disruption of exon 1 by insertion of a LacZ gene (in-frame with the initiation codon) and neomycin selection cassette without deletion of any of the endogenous gene sequence. T cells in this strain retain high levels of P2X7 activity. The 13a isoform is expressed in these mice but no expression of the 13b or 13c isoforms is detected.
(J:97422, J:101945, J:149750, J:194518)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any P2rx7 Mutation: |
52 strains or lines available
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| Original: |
J:97422 Sikora A, et al., Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism. J Immunol. 1999 Jul 15;163(2):558-61 |
| All: |
34 reference(s) |
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Analysis Tools
