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Slc28a1 Gene Detail
Summary
  • Symbol
    Slc28a1
  • Name
    solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
  • Synonyms
    Cnt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3605073
    NCBI Gene: 434203
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80764547-80820164 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3605073
 protein coding gene Chr7:80763017-80820164 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032425
 protein coding gene Chr7:83147203-83206590 (+)
A/J MGP_AJ_G0032404
 protein coding gene Chr7:81187672-81250354 (+)
AKR/J MGP_AKRJ_G0032340
 protein coding gene Chr7:82981049-83038321 (+)
BALB/cJ MGP_BALBcJ_G0032416
 protein coding gene Chr7:80849829-80903878 (+)
C3H/HeJ MGP_C3HHeJ_G0032129
 protein coding gene Chr7:83602058-83660471 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032908
 protein coding gene Chr7:86392696-86468955 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029916
 protein coding gene Chr7:83679569-83736314 (+)
CAST/EiJ MGP_CASTEiJ_G0031457
 protein coding gene Chr7:74509073-74571891 (+)
CBA/J MGP_CBAJ_G0032095
 protein coding gene Chr7:89300021-89365098 (+)
DBA/2J MGP_DBA2J_G0032250
 protein coding gene Chr7:79731099-79787714 (+)
FVB/NJ MGP_FVBNJ_G0032205
 protein coding gene Chr7:79660096-79716287 (+)
LP/J MGP_LPJ_G0032331
 protein coding gene Chr7:84382563-84441690 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032242
 protein coding gene Chr7:89388492-89445337 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032926
 protein coding gene Chr7:82397560-82453506 (+)
PWK/PhJ MGP_PWKPhJ_G0031177
 protein coding gene Chr7:72937060-72993316 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031018
 protein coding gene Chr7:69402985-69462092 (+)
WSB/EiJ MGP_WSBEiJ_G0031575
 protein coding gene Chr7:82757476-82814100 (+)



Homology
more
  • Human Ortholog
    SLC28A1, solute carrier family 28 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC28A1, solute carrier family 28 member 1
  • Synonyms
    CNT1, HCNT1, URCTU
  • Links
    NCBI Gene ID: 9154
    neXtProt AC: NX_O00337
    UniProt: O00337

  • Chr Location
    15q25.3; chr15:84884654-84975649 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    95
  • cDNA Data
    7
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025726 Ensembl Gene Model | MGI Sequence Detail 55618 C57BL/6J ±  kb
transcript ENSMUST00000026820 Ensembl | MGI Sequence Detail 2846 Not Applicable  
polypeptide ENSMUSP00000026820 Ensembl | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015051 sodium/nucleoside cotransporter 1
    (term hierarchy)
  • InterPro Domains
    IPR008276 Concentrative nucleoside transporter
    IPR011657 Concentrative nucleoside transporter C-terminal domain
    IPR018270 Concentrative nucleoside transporter, metazoan/bacterial
    IPR002668 Concentrative nucleoside transporter N-terminal domain
    IPR011642 Nucleoside transporter/FeoB GTPase, Gate domain
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:336148 Persaud AK, et al., Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice. Nat Commun. 2023 Jun 1;14(1):3175
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory