Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vdrtm1Tyam
Name:	vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Takeyoshi Yamashita
MGI ID:	MGI:3604810
Synonyms:	VDR-
Gene:	Vdr  Location: Chr15:97752308-97806177 bp, - strand  Genetic Position: Chr15, 53.85 cM
Alliance:	Vdrtm1Tyam page

Germline Transmission:	Earliest citation of germline transmission: J:101456
Parent Cell Line:	TT2F (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced the 83 bp internal sequence of exon 2. RT-PCR of mutant bone and kidney failed to detect transcript. (J:101456)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdr Mutation:	35 strains or lines available

Original:	J:101456 Shimada T, et al., Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am J Physiol Renal Physiol. 2005 Nov;289(5):F1088-95
All:	1 reference(s)