Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bace1tm2Psa
Name:	beta-site APP cleaving enzyme 1; targeted mutation 2, Paul Saftig
MGI ID:	MGI:3603597
Synonyms:	BACE1II
Gene:	Bace1  Location: Chr9:45749878-45775694 bp, + strand  Genetic Position: Chr9, 25.22 cM
Alliance:	Bace1tm2Psa page

Germline Transmission:	Earliest citation of germline transmission: J:100925
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Cre mediated recombination removed exon 2 from the locus. Expression was abolished in brain, liver and kidney as shown by quantitative RT-PCR. (J:100925)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:	27 strains or lines available

Original:	J:100925 Dominguez D, et al., Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005 Sep 2;280(35):30797-806
All:	1 reference(s)