Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grm8tm1Duv
Name:	glutamate receptor, metabotropic 8; targeted mutation 1, Robert M Duvoisin
MGI ID:	MGI:3603321
Synonyms:	mGlu8-, mGluR8-
Gene:	Grm8  Location: Chr6:27275120-28135094 bp, - strand  Genetic Position: Chr6, 11.97 cM, cytoband A3
Alliance:	Grm8tm1Duv page

Germline Transmission:	Earliest citation of germline transmission: J:101087
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 8, which encodes six of the seven predicted transmembrane segments. Both splice variants were undetectable by immunoblot. (J:101087)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grm8 Mutation:	68 strains or lines available

Original:	J:101087 Duvoisin RM, et al., Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. Eur J Neurosci. 2005 Jul;22(2):425-36
All:	7 reference(s)