Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Casp7tm1Flv
Name:	caspase 7; targeted mutation 1, Richard A Flavell
MGI ID:	MGI:3603317
Synonyms:	Casp7-
Gene:	Casp7  Location: Chr19:56385561-56430776 bp, + strand  Genetic Position: Chr19, 51.84 cM
Alliance:	Casp7tm1Flv page

Germline Transmission:	Earliest citation of germline transmission: J:59875
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The targeting construct replaces exons 2 and 3 with a neomycin resistance cassette, and also results in a frame-shift. Western blot analysis showed absence of caspase 7 expression in homozygous mice. (J:105496)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp7 Mutation:	16 strains or lines available

Original:	J:59875 Zheng TS, et al., Caspase knockouts: matters of life and death. Cell Death Differ. 1999 Nov;6(11):1043-53
All:	31 reference(s)