Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fhl2tm2Wlm
Name:	four and a half LIM domains 2; targeted mutation 2, R Sanders Williams
MGI ID:	MGI:3603305
Synonyms:	Fhl2LacZ+, FLH2-, FLH2LacZ/neo
Gene:	Fhl2  Location: Chr1:43162234-43236144 bp, - strand  Genetic Position: Chr1, 22.33 cM
Alliance:	Fhl2tm2Wlm page

Germline Transmission:	Earliest citation of germline transmission: J:100289
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The targeting vector was designed to replace the coding sequences from exon 2, including the translation initiation codon, the N-terminal half LIM motif, part of the LIM1 domain, and 0.5 kb of intron 2 with a lacZ reporter gene and a loxP flanked neomycin resistance cassette. Transcription of the lacZ insertion was evident in various stages of embryonic development. Absence of endogenous transcript and protein in mutants was confirmed by Northern and Western blots, respectively. (J:100289)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fhl2 Mutation:	16 strains or lines available

Original:	J:100289 Kong Y, et al., Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. Circulation. 2001 Jun 5;103(22):2731-8
All:	22 reference(s)