Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gcnt2tm1Tmu
Name:	glucosaminyl (N-acetyl) transferase 2 (I blood group); targeted mutation 1, Takashi Muramatsu
MGI ID:	MGI:3589370
Synonyms:	Ignt-
Gene:	Gcnt2  Location: Chr13:41013417-41114368 bp, + strand  Genetic Position: Chr13, 20.12 cM, cytoband A5
Alliance:	Gcnt2tm1Tmu page

Germline Transmission:	Earliest citation of germline transmission: J:100533
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A 2.0-kb portion of exon 3 sequence encoding the catalytic domain common to all three splice variants was deleted via homologous recombination. Northern blot failed to detect transcript in livers from mutant mice. RT-PCR failed to detect transcript in cerebellum and kidney samples from mutants. (J:100533)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcnt2 Mutation:	88 strains or lines available

Original:	J:100533 Chen GY, et al., Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice. Mol Cell Biol. 2005 Sep;25(17):7828-38
All:	1 reference(s)