Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sit1tm1Lsmn
Name:	suppression inducing transmembrane adaptor 1; targeted mutation 1, Luca Simeoni
MGI ID:	MGI:3588572
Synonyms:	SIT-
Gene:	Sit1  Location: Chr4:43482083-43483709 bp, - strand  Genetic Position: Chr4, 23.04 cM
Alliance:	Sit1tm1Lsmn page

Germline Transmission:	Earliest citation of germline transmission: J:100408
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding sequence was replaced with a neomycin resistance cassette. Western blot confirmed successful targeting in mutants and ablation of translation. (J:100408)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sit1 Mutation:	14 strains or lines available

Original:	J:100408 Simeoni L, et al., The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Mol Cell Biol. 2005 Sep;25(17):7557-68
All:	4 reference(s)