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Cyp8b1tm1Rus
Targeted Allele Detail
Summary
Symbol: Cyp8b1tm1Rus
Name: cytochrome P450, family 8, subfamily b, polypeptide 1; targeted mutation 1, David Russell
MGI ID: MGI:3588415
Synonyms: Cyp8b1-
Gene: Cyp8b1  Location: Chr9:121743422-121745371 bp, - strand  Genetic Position: Chr9, 72.73 cM, cytoband F4
Alliance: Cyp8b1tm1Rus page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100206
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding region was replaced with beta-galactosidase coding sequence and a neomycin resistance gene in reverse orientation. Transcript was not detected in livers of mutant mice. (J:100206)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp8b1 Mutation:  32 strains or lines available
References
Original:  J:100206 Li-Hawkins J, et al., Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest. 2002 Oct;110(8):1191-200
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory