Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Afmidtm1Vnd
Name:	arylformamidase; targeted mutation 1, Vasily N Dobrovolsky
MGI ID:	MGI:3588407
Gene:	Afmid  Location: Chr11:117716750-117730734 bp, + strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Alliance:	Afmidtm1Vnd page

Germline Transmission:	Earliest citation of germline transmission: J:100247
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette was inserted and replaced the 5' promoter region, first exon and part of intron 1 of Afmid. The construct also replaced the 5' promoter region, first exon, first intron and a portion of exon 2 of Tk1. Afmid mRNA was not detected in mutant liver, kidney and salivary gland. (J:100247)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Afmid Mutation:	37 strains or lines available

Original:	J:100247 Dobrovolsky VN, et al., Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype. Biochim Biophys Acta. 2005 Jun 20;1724(1-2):163-72
All:	2 reference(s)